Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics studyArticle Published on 2022-10-142022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abuse Accelerator Antibody Response association Biomarker BNT162b2 characterized clinical trial coronavirus Course COVID-19 COVID-19 patients Critical CXCL10 cytokine dataset develop Disease progression Donor drug early IFN signaling Eiger BioPharmaceuticals enrolled Enrollment heterogeneity Host identify immune immune marker immune response immune signature immunological immunology independent individual Infection Infectious disease Inflammation machine-learning majority marker MCP-3 MCP1 Medicine memory Mild mRNA vaccination natural infection outcome Outpatient outpatients Patient Pfizer-BioNTech plasma plasma protein Post-infection predict Predictive Predictive modeling proteomics provided receiving RIG-I SARS-CoV-2 SARS-CoV-2-infected patients severe symptoms Stanford Stanford University subsequent systems immunology T cell T cell memory the antibody response trajectory transcriptomics Vaccine viral shedding Virological viruses viruses. with COVID-19 [DOI] 10.7554/eLife.77943 PMC 바로가기
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregatesArticle Published on 2022-10-052022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while [DOI] 10.3389/fimmu.2022.861251 PMC 바로가기
Comparison between enzyme-linked immunospot assay and intracellular cytokine flow cytometry assays for the evaluation of T cell response to SARS-CoV-2 after symptomatic COVID-19Article Published on 2022-10-012022-11-15 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence Adaptive immune response anti-SARS-CoV-2 assays cellular cellular immunity correlated COVID-19 Culture detectable ELISPOT ELISpot assay enzyme-linked immunospot assay flow cytometry assay ICS Immunity IMPROVE intracellular cytokine intracellular cytokine staining intracellular cytokine staining assay magnitude median memory T memory T cells mononuclear cell nucleoprotein of SARS-CoV-2 Patient patients paucisymptomatic COVID-19. peptide pool performed Peripheral blood positive proportion response SARS-CoV-2 severe COVID-19 severe disease severe symptoms symptomatic T cell T cell response T cells the spike protein Vaccine-induced immunity [DOI] 10.1002/iid3.617 PMC 바로가기
Antibiotic prescribing trends in the US during the first 11 months of the COVID-19 pandemicObservational Study Published on 2022-10-012022-10-04 Journal: Research in social & administrative pharmacy : RSA [Category] 임상, [키워드] analytical sample antibiotic Antibiotic appropriateness Antibiotic prescribing Antibiotics calculated category Cohort cohorts COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients demographic characteristics Descriptive statistics Diagnosis diagnosis of COVID-19 disease severity group had no majority Mild mild COVID-19 mild COVID-19 symptoms mild symptoms moderate much lower no symptoms Non-COVID-19 non-COVID-19 cohort Non-COVID-19 patients Non-severe COVID-19 pandemic Patient patients with moderate positive positive COVID-19 proportion receiving retrospective Sample severe COVID-19. severe symptoms Symptom Symptoms use of antibiotics widespread [DOI] 10.1016/j.sapharm.2022.05.008 PMC 바로가기 [Article Type] Observational Study
Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 ActivityArticle Published on 2022-09-222022-11-15 Journal: Journal of medicinal chemistry [Category] SARS, 변종, 치료제, [키워드] Activation activity analogue antiviral activity antiviral drug antiviral potency Antiviral treatment Concentration COVID-19 COVID-19 patient Efficacy FDA-approved drug hamsters hydrolysis lack lung lung epithelial cell Lungs metabolite moiety NTP nucleoside optimization Patient patients plasma Premature prodrug reducing Remdesivir severe symptom severe symptoms tissue treat variants of SARS-CoV-2 [DOI] 10.1021/acs.jmedchem.2c00758 PMC 바로가기
Antibody levels after BNT162b2 vaccine booster and SARS-CoV-2 Omicron infectionArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, [키워드] administration antibody antibody level Antibody Response BNT162b2 vaccine booster booster dose booster vaccination COVID-19 decrease Delta evaluated HCW HCWs healthcare worker humoral immune response immune immunisation Immunisation safety Immunity immunogenicity data increase in Infection much higher naïve Neutralizing antibodies of BNT162b2 omicron Omicron variant resulting SARS-CoV-2 SARS-CoV-2. second dose second vaccination severe symptoms Support the vaccine threshold Vaccine variant virus [DOI] 10.1016/j.vaccine.2022.08.045 PMC 바로가기
Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasmaArticle Published on 2022-09-012022-11-15 Journal: The Journal of Clinical Investigation [Category] SARS, 치료기술, [키워드] Blood blood donor cell line clinical Clinical practice cough COVID-19 COVID-19 mortality COVID-19 patient detectable detection Diagnosis diagnosis of COVID-19 Donor General population implementation Infectious virus Influenza information lack less Limits of detection mice Mild Molecular diagnosis. Pathogenesis PDI peaked plaque-forming unit plasma presymptomatic produced question raise reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe symptoms Shortness of breath susceptible Symptom tested unlikely vaccination virus widespread [DOI] 10.1172/JCI159876 PMC 바로가기
Prediction of Potential Commercially Available Inhibitors against SARS-CoV-2 by Multi-Task Deep Learning Model다중 작업 딥 러닝 모델을 통한 SARS-CoV-2에 대한 잠재적으로 상업적으로 이용 가능한 억제제 예측Article Published on 2022-08-212022-09-11 Journal: Biomolecules [Category] SARS, 치료제, [키워드] binding binding mode binding modes can be used caused Compound COVID-19 dataset datasets death deep deep learning drug Drug discovery effective effective drug effective drugs effective inhibitor effort exhibited fine-tune help heterogenous identify Infection inhibitors Interaction learning Model molecular docking multi-task learning outbreak performed Potential predicted prediction Prevent protein-ligand interaction protein–ligand interaction. rising SARS-CoV-2 SARS-CoV-2 protein selected severe symptoms targets was collected was used [DOI] 10.3390/biom12081156 PMC 바로가기 [Article Type] Article
The association of APOE genotype with COVID-19 disease severityAPOE 유전자형과 COVID-19 질병 중증도의 연관성Article Published on 2022-08-052022-09-11 Journal: Scientific Reports [Category] 변종, 유전자 메커니즘, [키워드] affected allele ApoE APOE gene association asymptotic caused control group COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient Critical Critical illness disease disease severity e4 allele exclusion explain FIVE Genetic predisposition Genotype global health Health increase in increased the risk individuals mechanism Mild multiplex pandemic Patient patients with asymptomatic PCR method predisposition respiratory infection Result risk risk factor Risk factors severe disease severe or critical illness severe symptom severe symptoms severity severity of COVID-19 Study design study population Symptom the disease underlying disease underlying diseases Variation was performed with COVID-19 [DOI] 10.1038/s41598-022-17262-4 PMC 바로가기 [Article Type] Article